PUBLICATIONS
Dissertation:
1. Grafting and Interaction of Water-soluble
Synthetic Polymers with Liposomes, Ph.D.
dissertation,
Peer Reviewed Scientific Articles:
1. Thakur, R., Kunadharaju, S., and Savva, M., Kinetic and thermodynamic characterization of camptothecin hydrolysis at physiological pH in the absence and presence of human serum albumin. International Journal of Chemical Kinetics. Accepted for publication 05-22-2009.
2. Kunadharaju, S., Savva, M., Thermodynamic studies of 10-hydroxy-camptothecin in aqueous solutions. Journal of Chemical & Engineering Data. Accepted for publication 06-07-2009.
3. Savva, M., Acheampong, S., The interaction energies of cholesterol and 1,2-dioleoyl-phosphoethanolamine in spread mixed monolayers at the air-water interface. The journal of Physical Chemistry B. Accepted for publication 06-09-2009.
4. Kunadharaju, S., Savva, M., Kinetic and thermodynamic analysis of 10-hydroxy-camptothecin hydrolysis at physiological pH. Journal of Chemical Thermodynamics 40: 1439-1444 (2008).
5. Savva, M., Sivakumar, B., Selvi, B., The Conventional Langmuir Trough Technique as a Convenient Means to Determine the Solubility of Sparingly Soluble Surface Active Molecules: Case Study Cholesterol. Colloids and Surfaces A: Physicochemical and Engineering Aspects 325: 1-6 (2008).
6. Selvi, B., Patel, S., and Savva, M., Physicochemical Characterization and Membrane Binding Properties of Camptothecin. Journal of Pharmaceutical Sciences 97: 4379-90 (2008).
7.
8. Spelios, M., and Savva, M., Novel N,N'-diacyl-1,3-diaminopropyl-2-carbamoyl bivalent cationic lipids for gene delivery: synthesis, in vitro transfection activity, and physicochemical characterization. FEBS Journal 275: 148-162 (2008).
9. Aljaberi, A., Spelios, M.,
10. Spelios, M., Nedd, S., Matsunaga, N. and
Savva, M., Effect of spacer attachment sites
and pH-sensitive headgroup expansion on cationic
lipid-mediated gene delivery of three myristoyl
derivatives. Biophysical Chemistry
129: 137-147 (2007).
11. Khairuzzaman, A., Ahmed, S. U., Savva, M., Patel, N. K., Zero order release of Aspirin, Theophylline and Atenolol in water from a novel methylcellulose glutarate matrix tablets. International Journal of Pharmaceutics 318: 15-21 (2006).
12. Savva, M. Uncertainty Analysis of Drug Concentration in Pharmaceutical Mixtures Analytical Chemistry Insights, 2: 1-3 (2006).
13. Savva, M., Chen P., Aljaberi, A., Selvi, B., Spelios, M., In vitro Lipofection With Novel Asymmetric Series of 1,2-dialkoylamidopropane- based Cytofectins Containing Single Symmetric bis-(2-dimethylaminoethane) Polar Head Groups. Bioconjugate Chemistry 16: 1411-1422 (2005).
14. Savva, M., Aljaberi, A., Feig, J. and Stolz D.B. Correlation of the physicochemical properties of symmetric 1,3-dialkoylamidopropane-based cationic lipids containing single primary and tertiary amine polar head groups with in vitro transfection activity. Colloids and Surfaces B: Biointerfaces 43: 43-56 (2005).
15. Aljaberi, A., Savva, M.,
Synthesis, in vitro transfection activity and
physicochemical characterization of novel N,N'-diacyl-1,2-diaminopropyl-3-carbamoyl-(dimethylaminoethane) amphiphilic
derivatives. Chemistry and Physics of Lipids 133: 135-149 (2005).
16. Sheikh, M., Feig, J., Gee, B., Li, S. and Savva, M., In vitro lipofection with novel series of symmetric 1,3-dialkoylamidopropane-based cationic surfactants containing single primary and tertiary amine polar head groups. Chemistry and Physics of Lipids 124: 49-61 (2003).
17. Yamazaki. Y., Savva, M., and Mokotoff, M., Enhanced cleavage of diaminopimelate-containing isopeptides by leucine aminopeptidase and matrix metalloproteinases in tumors: Application to bioadhesive peptides. Journal of Peptide Research 53: 177-187 (1999).
18. Savva, M., Duda, E., and Huang, L., A genetically modified recombinant tumor necrosis factor-a conjugated to the distal terminals of liposomal surface grafted polyethyleneglycol chains. International Journal of Pharmaceutics 184: 45-51 (1999).
19. Savva, M., and Huang, L., Effect of peg homopolymer and grafted amphiphilic peg-palmityl on the thermotropic phase behavior of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine bilayer. Journal of Liposome Research 9: 357-366 (1999).
20. Savva, M., Torchilin, P.V., and Huang, L., Effect of Poly(vinylpyrrolidone) on the thermal phase transition of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine bilayer. Implications in Pharmaceutical processing and drug delivery. Journal of Colloid and Interface Science 217: 160-165 (1999).
21. Savva, M., Torchilin, P.V., and Huang, L., Effects of grafted amphiphilic PVP-palmityl polymers on the thermotropic phase behavior of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine bilayer. Journal of Colloid and Interface Science 217: 166-171 (1999).
HONORS
1. Michael Spelios was selected as one of the New York City University Student Poster Presenter Winners of the 2008 CRS Annual Meeting & Exposition a complementary.
2. Molinda Kearn's abstract was judged the runner-up for the 2008 NJPhAST Graduate Scholarship award ($1,000 and poster presentation).
3. Sasank Kunadharaju's abstract has been recommended by the scientific reviewers to be the recipient of the 2008 NJPhAST Graduate Scholarship ($2,000 and podium talk).
INVITED TALKS
1. Savva, M., Torchilin, P.V., and
Huang, L., PVP: a pretender molecule. Podium Presentation at
the 25th international symposium on Controlled Release of Bioactive Materials.
June 21-26,
BOOKS
1. Michalakis Savva, “Rational
Approach to Pharmaceutical Calculations” 1st Edition, Vagma, LLC,
2. Michalakis Savva, “Rational
Approach to Pharmaceutical Calculations: Solutions and Comments on the
Problems” 1st Edition, Vagma, LLC,
1. “Methods and products for error determination of drug dose in pharmaceutical mixtures”
The invention
discloses a computer system and program product including an algorithm for
computing the uncertainty of drug concentration in pharmaceutical dosage forms.
The invention also determines
the sensitivity of the instruments measuring each of the components and the
least allowable weight (LAW) within a maximum allowable error of each
ingredient at the predetermined
assay standard. The program product and system allow the
accurate error evaluation of
drug dose in pharmaceutical mixtures and unit dosage forms, composed of an
infinite number of ingredients that are measured on multiple equipments of
variable sensitivities thus, providing
instant guidance on the pharmaceutical ingredient preparation.
At the moment, the program is established as a Web-based computational service www.vagmapharm.com to pharmacy students, compounding pharmacists and pharmaceutical scientists working as formulators in pharmaceutical companies.
1. “Single-components pH-sensitive cationic liposomes of increased membrane fluidity”. Publication #: US-2005-0095280-A1 Publication date: 05-05-2005
2. “Cationic lipids for nucleic acid delivery”. Publication #: US-2005-0084522-A1 Publication date: 04-21-2005
3. “Methods and products for error determination of drug dose in pharmaceutical mixtures”
Application Submitted to USPTO: 08/21/2006